Rash - Widespread and Cause Unknown  
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This Care Guide Covers:

  • Rash over most of the body (widespread)
  • Sometimes just on hands, feet, and buttocks - but symmetrical
  • Small spots, large spots, or solid red
  • Cause of rash is unknown

If not, see these topics
View images
Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever

Chickenpox on Abdomen
Chickenpox on Abdomen

Penicillin Rash on the Arm
Penicillin Rash on the Arm

Scarlet Fever Rash
Scarlet Fever Rash

Chickenpox Rash
Chickenpox Rash

When to Call Your Doctor

Call 911 Now (you may need an ambulance) If
  • Very weak (can't stand)
  • Purple or blood-colored rash with fever
  • Rash started quickly within the past 2 hours and trouble breathing or swallowing
  • Trouble waking up or acting confused
  • Life-threatening reaction in the past to the same thing (food, insect bite/sting, chemical) and less than 2 hours since exposed
  • You think you have a life-threatening emergency
Call Your Doctor Now (night or day) If
  • You feel weak or very sick
  • Purple or blood-colored rash without fever
  • Bright red skin that peels off in sheets
  • Bright red, sunburn-like rash after wound infection or recent surgery
  • Bright red, sunburn-like rash after tampon use or nasal packing
  • Rash looks like blisters (fluid-filled bubbles or sacs on the skin)
  • Rash began within 4 hours of taking a new prescription drug
  • Fever
  • Headache
  • Stiff neck (cannot touch chin to chest)
  • Joint pain or swelling
  • Sores in the mouth
Call Your Doctor Within 24 Hours (between 9 am and 4 pm) If
  • A widespread rash, but none of the problems described above
Causes & Health Information

Some Basics...

CARE ADVICE FOR WIDESPREAD RASHES (While Waiting to Talk to Your Doctor)

  1. What You Should Know:
    • Many causes of widespread rashes are not serious.
    • Causes include viruses like a cold. Allergic reactions to a food, drug, plant, or insect bite can also cause rashes.
    • You can treat most widespread rashes at home.
    • Here is some care advice that should help.
  2. For Non-Itchy Rashes:
    • No treatment is needed, except for heat rashes.
    • A heat rash can be treated with a cool bath or shower.
  3. For Itchy Rashes:
    • Wash the skin once with gentle, unscented soap to remove any irritants. Rinse the soap off.
    • You may also take an oatmeal (Aveeno) bath to help with the itching. You can also take an antihistamine.
  4. Oatmeal Bath for Itching: Sprinkle contents of one Aveeno packet under warm running water. Bathe for 15-20 minutes. Do this 1-2 times a day. Pat dry with a towel. Try not to rub.
  5. Antihistamine Drugs for Itching: Take an antihistamine to help with the itching. Diphenhydramine (Benadryl) is a good choice. It is sold over-the-counter (OTC).The adult dose is 25-50 mg. You can take it up to 4 times a day.
    • Do not take these drugs if you have an enlarged prostate.
    • They may make you feel tired. Do not drink, drive, or use dangerous machinery while taking antihistamines.
    • An OTC antihistamine that causes less sleepiness is loratadine (Alavert or Claritin).
    • Read all package instructions.
  6. How It Is Spread: Avoid contact with pregnant women until you see a doctor. Most viral rashes can be spread. If you also have a fever, the rash is more likely to spread. Return to school or work after the rash is gone or your doctor says that you can.
  7. What to Expect: Most viral rashes go away within 48 hours.
  8. Call Your Doctor If:
    • You get worse

Remember! Call your doctor if any of the "When to Call" symptoms occur.

Disclaimer: This information is not intended be a substitute for professional medical advice. It is provided for educational purposes only. You assume full responsibility for how you choose to use this information.


Author and Senior Reviewer: David A. Thompson, M.D.

Last Reviewed: 9/1/2012

Last Revised: 10/31/2012

Content Set: Adult Symptom Checker

Copyright 2000-2012. Self Care Decisions LLC; LMS, Inc.